OTC Analgesic Interactions & Contraindications

62% of consumers choose pain relievers based on efficacy and not important safety factors1

You can help your patients make an appropriate choice.

90% of consumers depend on OTC pain relievers to manage their pain,1 but they may not realize that age, coexisting medical conditions, and drug contraindications are important factors when choosing an OTC analgesic. Your guidance can help them find safe and effective pain management.

Review key considerations for recommending acetaminophen, ibuprofen, aspirin, and naproxen sodium.

Drug contraindications & interactions for specific OTC analgesics

Acetaminophen icon

65% of consumers do not consider…

Aspirin icon

50 million American adults…


Only 12% of consumers are aware…


58% of consumers do not consider…

References: 1. U.S. Pain Foundation. One in five Americans do not consider any key safety factors when choosing over-the-counter pain relievers [press release]. Fort Washington, Pa: PRNewswire/USNewswire. August 29, 2016. 2. Risser A, Donovan D, Heintzman J, Page T. NSAID prescribing precautions. Am Fam Physician. 2009;80(12):1371-1378. 3. Bhatt DL, Scheiman J, Abraham NS, et al. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. Circulation. 2008;118(8):1894-1909. 4. Calhoun DA, Jones D, Textor S, et al. Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension. 2008;51:1403-1419.