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Acetaminophen Metabolism in the Liver

Acetaminophen Metabolism in the Liver

Get a useful overview of acetaminophen hepatic metabolism, which occurs through 3 distinct pathways.1-3

Understand the metabolic process when acetaminophen is taken at recommended doses, as well as in acute acetaminophen overdose.

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References: 1. Patten CJ, Thomas PE, Guy RL, et al. Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. Chem Res Toxicol. 1993;6(4):511-518. 2. Raucy JL, Lasker JM, Lieber CS, Black M. Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2. Arch Biochem Biophys. 1989;271(2):270-283. 3. Thummel KE, Lee CA, Kunze KL, Nelson SD, Slattery JT. Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4. Biochem Pharmacol. 1993;45(8):1563-1569.